It would be worthwhile if the less frequent injections are a big advantage for you…depending on the cost of course. It may be more expensive to switch to Aranesp, so that would be a factor as well.

There is a good bit more clinical data and experience with Procrit, but no evidence to suggest that one is “better” or safer than the other. So to me, the only two factors are going to be convenience and cost. 

Lastly, depending on the reason you need Procrit, you may want to talk with your healthcare provider about modifying your target hemoglobin. Last year, the FDA issued an advisory recommending more conservative hemoglobin targets for kidney disease patients in light of the risks of Procrit or Aranesp treatment. As a general rule, you probably shouldn’t start on it until your hemoglobin is falling below 10, and your goal for treatment should not exceed 10-11. 

http://themedicineguy.com/post/6936015666/fda-warning-anemia-drugs

Hope this helps!

-Aaron Emmel, Pharm.D., BCNSP, BCPS